ADC Payloads
ADC Cytotoxins
ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.
There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.
ADC Payloads Isoform Specific Products
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ADC Payloads
(217)
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Auristatin
(15)
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Calicheamicins
(1)
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Camptothecins
(42)
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Daunorubicins/Doxorubicins
(11)
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Duocarmycins
(18)
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Maytansinoids
(9)
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Pyrrolobenzodiazepines
(8)
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Traditional Cytotoxic Agents
(24)
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All Product Categories
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ADC Payloads Related Products (370)
Related Products (370)
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Antibodies (2)
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Related Compound Screening Libraries (1)
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ADC Payloads Isoform Comparison
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thioxo-Dxd
0 ImagesCat. No.: HY-178262ACAS No.: 2806052-35-5thioxo-Dxd is a Camptothecin (HY-16560) derivative. thioxo-Dxd can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. thioxo-Dxd can be used for research on tumors with high HER2 or TROP2 expression.
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Py-MPB-amino-C3-PBD
0 ImagesCat. No.: HY-135901CAS No.: 2412924-07-1Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.
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7-MAD-MDCPT-AC-(s-cyclopropane)
0 ImagesCat. No.: HY-179204CAS No.: 2911575-71-67-MAD-MDCPT-AC-(s-cyclopropane) is a derivative of camptothecin. 7-MAD-MDCPT-AC-(s-cyclopropane) can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. 7-MAD-MDCPT-AC-(s-cyclopropane) can be used for cancer research.
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RNA polymerase II-IN-2
0 ImagesCat. No.: HY-147917CAS No.: 2891451-33-3RNA polymerase II-IN-2 is a RNA polymerase II inhibitor with a Ki value of 74.1 nM. RNA polymerase II-IN-2 inhibits Pol II-mediated transcription and induces cytotoxicity in mammalian cells. RNA polymerase II-IN-2 serves as a payload for antibody-drug conjugates (ADC) and is applicable for cancer research.
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Muscotoxin A
0 ImagesCat. No.: HY-131058CAS No.: 1653999-47-3Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death.
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Gly-7-MAD-MDCPT hydrochloride
0 ImagesCat. No.: HY-132164APurity: 98.27%Gly-7-MAD-MDCPT (Compound 4b) hydrochloride is an anticancer agent. Gly-7-MAD-MDCPT hydrochloride is a Camptothecin (HY-16560) compound, which shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM.
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Dimethyl-SGD-1882
0 ImagesCat. No.: HY-126678CAS No.: 3026416-27-0Synonyms: Dimethyl-PBD dimerDimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication.
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Seco-DUBA hydrochloride
0 ImagesCat. No.: HY-132180CAS No.: 1795733-93-5Seco-DUBA hydrochloride is a toxin for ADC drug SYD985.
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MYX1715 analog 1
0 ImagesCat. No.: HY-183263CAS No.: 3119468-32-2MYX1715 analog 1 is an analog of MYX1715 (HY-164285). MYX1715 analog 1 is an N-myristoyltransferase (NMT) inhibitor that inhibits protein myristoylation modification. MYX1715 analog 1 can be conjugated to targeting antibodies via cleavable or non-cleavable linkers for use as an ADC cytotoxin. MYX1715 analog 1 is used in the development of drugs targeting tumor-associated antigens.
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TLR7 agonist 32
0 ImagesCat. No.: HY-167774CAS No.: 1821304-87-3TLR7 agonist 32 (payload P3), a TLR7 agonist, is an ADC payload taht can be used in the synthesis of antibody-drug-conjugates (ADCs).
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7-MAD-MDCPT TFA
0 ImagesCat. No.: HY-132162BCAS No.: 2378428-15-87-MAD-MDCPT TFA, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
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eIF4A-IN-2
0 ImagesCat. No.: HY-176843CAS No.: 3083974-69-7eIF4A-IN-2 (Compound 93) is an Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
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Seco-Duocarmycin TM
0 ImagesCat. No.: HY-130083CAS No.: 236102-87-7Seco-Duocarmycin TM is a DNA alkylator agent belonging to Duocarmycins family that inhibits DNA synthesis. Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates (ADC)[1].
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Spiro-duocarmycin
0 ImagesCat. No.: HY-160969CAS No.: 1642147-15-6Spiro-duocarmycin is a DNA minor groove N3-adenine alkylating agent. Spiro-duocarmycin exerts cytotoxic effects via DNA alkylation. Spiro-duocarmycin is the active spirocyclized form of seco-DUBA, which is incorporated as an inactive prodrug into the linker-drug construct of antibody-drug conjugates (ADCs). DUBA serves as an ADC payload that can be conjugated with monoclonal antibodies to synthesize antibody-drug conjugates (ADCs).
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Cryptophycin analog 1
0 ImagesCat. No.: HY-107502CAS No.: 1260431-28-4Cryptophycin analog 1 is an ADC payload. Cryptophycin analog 1 shows anticancer activity. Cryptophycin analog 1 displays cell activity an order of magnitude more potent than approved ADC payloads MMAE and DM1.
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Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol
![Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol](https://file.medchemexpress.com/product_pic/hy-160598.gif "Click to View Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol Product Detail")
0 ImagesCat. No.: HY-160598CAS No.: 2891774-71-1Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol (compound 45) is a camptothecin compound that can inhibit cell proliferation, with an IC50 of 2.92 ng/mL for MDA‑MB‑468 cells. Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol can be used for the research of cancer.
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Tubulysin IM-3
0 ImagesCat. No.: HY-130960CAS No.: 1639986-05-2Tubulysin IM-3 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.
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Exatecan-amide-bicyclo[1.1.1]pentan-1-ol
![Exatecan-amide-bicyclo[1.1.1]pentan-1-ol](https://file.medchemexpress.com/product_pic/hy-160597.gif "Click to View Exatecan-amide-bicyclo[1.1.1]pentan-1-ol Product Detail")
0 ImagesCat. No.: HY-160597CAS No.: 2866299-06-9
